Aging is not a disease, but it is a process of decreasing physiological and biochemical efficiencies in different pathways like telomere length protection, mitochondrial dysfunction due to DNA damage, accumulation of free radicals, protein misfolding and decrease of protein turnover, declining of stem cell repertory and stem cell turnover, chronic diseases, savior traumas due to accidents and chronic inflations. Our research team has developed disruptive technologies for reversal of aging in two ways: molecular rejuvenation of the whole organism and multi-organ molecular regeneration.
The answer to this question is surely “yes.” There are two ways to resolve aging complications: molecular regeneration of multi-organ works on chronic diseases in different organs and Molecular rejuvenation transforms aged cells into young cells.
We have been experiencing groundbreaking changes in different fields of science with the advent of artificial intelligence; similarly, medical science is also going to experience a new disruptive innovation, i.e., molecular regeneration and molecular rejuvenation.
It is the high time to redefine Yamanaka’s induced pluripotency as a therapy for anti-aging (therapeutic reversal of aged somatic cells into young embryonic cells). Our team has focused on molecules for multi-organ regeneration and whole organism rejuvenation.
We have successfully completed the in vivo safety trials of the molecules for multi-organ regeneration and rejuvenation. Data of this research study was published in the peer-reviewed journal Biology Open. At present, we have also successfully completed renal function recovery in chronic kidney-diseased rats. Data of this study was submitted to the Indian patent. Now our team is planning the synthesis of human-specific nephrogenic proteins to start phase 1 1trails.
Biological function of enzymes is catalytic function, similarly hormones performs regulatory function, while the molecules involved in tissue differentiation, organogenesis will also applicable to adult stage diseased organ function recovery.
Biological function of growth factors is proven with In-vitro organoids developments, and our safety study “Safety assessment of rat embryonic fraction for in vivo regenerative therapy” published research data is assuring for the application of growth factors for multi-organ regeneration and rejuvenation in adult stage diseases, so this molecular regeneration and rejuvenation in adult stage diseases can turn into a disruptive technology in medical science that will leads to a phenomenal change by enhancing the lifespan of human.
Our preclinical study in CKD rats has proven the regeneration renal tissue and this study had paved a path way for treatment of human chronic kidney disease, so to we can completely avoid dialysis and transplantation.
Anti-aging includes, stopping advancement of aging and reversal of aging, in the course of clinical treatment two distinct methods needs to be implemented molecular regenerative therapy to achieve optimal physiological function of all organs and molecular rejuvenation for complete reversal of cellular aging , so that it helps in extending the lifespan with optimal health span.
Our genome itself is a coding source for regenerative and rejuvenative molecules, for the experimentation in lower animals we have utilized embryos as source.